Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202104347
Keywords
asymmetric catalysis; cationic iridium; C-H bond activation; decarbonylation; decarbonylative arylation
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Funding
- Japan Society for the Promotion of Science (JSPS, KAKENHI) [JP19K15575]
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We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. This asymmetric C-C bond formation is achieved through the decarbonylation of aldehydes catalyzed by chiral iridium complexes and the formation of an aryl-iridium intermediate. The reaction shows broad functional group compatibility and generates no waste apart from carbon monoxide.
We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asymmetric C-C bonds through the formation of an aryl-iridium intermediate. The decarbonylative aryl addition to bicyclic alkenes was fluidly performed without a stoichiometric aryl-metal reagent, such as aryl boronic acid, with a cationic iridium complex generated in situ from Ir(cod)(2)(BAr4F) and the sulfur-linked bis(phosphoramidite) ligand ((R,R)-S-Me-BIPAM). This reaction has broad functional group compatibility, and no waste is generated, except carbon monoxide.
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