19F MRI Probes for Multimodal Imaging

Magnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft-tissue contrast. This review discusses developments in the field of F-19 MRI multimodal probes in combination with optical fluorescence imaging (OFI), H-1 MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X-ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal F-19 MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing F-19 MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.

Automated summary

This review discusses the application of multimodal F-19 MRI probes in combination with various imaging techniques, highlighting their ability to compensate for the limitations of individual techniques and improve detection sensitivity and accuracy. Strategies for designing F-19 MRI multimodal probes are also described.