4.6 Article

MicroRNA-Triggered Nanozymes Cascade Reaction for Tumor-Specific Chemodynamic Therapy

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 72, Pages 18201-18207

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103547

Keywords

cascade reaction; chemodynamic therapy; miRNA-21; nanozyme; tumor specificity

Funding

  1. National Key R&D Program of China [2019YFA0709202]
  2. NSFC [91856205, 21820102009, 21871249, 21977091, CAS QYZDJSSW-SLH052]
  3. Jilin Province Science and Technology Development Plan Project [20200201241JC]

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The study presents a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy, where the cascade reaction can be successfully triggered by high microRNA expression in cancer cells to generate more (OH)-O-. and demonstrate excellent tumor-specific therapeutic performance. This work provides a new dimension for tumor-specific chemodynamic therapy.
Off-target toxicity and insufficient hydroxyl radicals ((OH)-O-.) generation limit the further clinical application of nanozymes in chemodynamic therapy (CDT). Herein, we designed and constructed a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy. The nanozyme-based cascade reaction could be triggered successfully by the high expression of microRNA in cancer cells to generate more (OH)-O-., thus exhibiting excellent tumor-specific therapeutic performance. Our work provides a new dimension for tumor-specific chemodynamic therapy.

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