Design, Synthesis, and Evaluation of Novel L-Pyroglutamic Acid Derivatives as Potent Antifungal Agents

A series of novel L-pyroglutamate containing 1,2,3-triazole ring substructures was synthesized and characterized by adopting an appropriate synthetic scheme. The effect of different substituents on the triazole ring at the ortho-, meta- and para-positions of the benzene ring was evaluated for the inhibition of zoospore release activity against Phytophthora infestans. Among the triazole analogs of L-pyroglutamate, compounds with a phenyl or benzyl group on the triazole ring at the meta-position of the benzene ring showed potent antifungal activity. Results indicated that some of the L-pyroglutamic acid derivatives possessed antifungal activity against Phytophthora infestans.

Automated summary

A series of novel L-pyroglutamate derivatives containing 1,2,3-triazole ring substructures were synthesized and evaluated for their antifungal activity against Phytophthora infestans. Compounds with phenyl or benzyl substituents at the meta-position of the triazole ring exhibited potent antifungal activity. Some of the L-pyroglutamic acid derivatives showed promising antifungal activity against Phytophthora infestans.