Journal
CHEMISTRY LETTERS
Volume 51, Issue 2, Pages 208-211Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.210700
Keywords
Bioimaging; IR-1061; OTN-NIR
Categories
Funding
- JSPS KAKENHI [19H01179, 21K15577]
- JJST through the Center of Innovation (COI) Program (COINS) [JPMJCE1305]
- National Cancer Center through the Research and Development Fund [31-A-11]
- Superhuman Medical Care Project
- Grants-in-Aid for Scientific Research [21K15577] Funding Source: KAKEN
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Fluorescence imaging in the over-thousand nanometer NIR wavelength region is a new technique for real-time bioimaging. The investigation showed that the OTN-NIR probe based on DSPE-PEG micelles is unstable in albumin and PBS solutions, but remains stable in water and saline.
Fluorescence imaging in the over-thousand nanometer (OTN-) near-infrared (NIR) wavelength region is an emerging technique for real-time bioimaging. OTN-NIR probes are made from micellar nanoparticles encapsulating IR-1061 dye in the core of poly(ethylene glycol) (PEG) phospholipid (PL), such as 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-N-[methoxy PEG] micelles. The property investigation revealed that the probe is less stable in albumin and PBS while remaining unchanged in water and saline. The results are critical for applying OTN-NIR probe from DSPE-PEG micelles in physiological environments.
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