Journal
CHEMISTRY LETTERS
Volume 51, Issue 2, Pages 153-156Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.210668
Keywords
Indole; Photoremovable protecting group; Two-photon excitation
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Funding
- JSPS KAKENHI [21H01921]
- JST CREST [JPMJCR18R4]
- Ikegami Foundation
- Grants-in-Aid for Scientific Research [21H01921] Funding Source: KAKEN
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Due to UV light-induced cell damage, photoremovable protecting groups (PPGs) that can be removed using visible or near-infrared light have gained attention. A novel PPG, 2-(4-nitrophenyl)-1H-indolyl-3-methyl chromophore (NPIM), was synthesized. Various compounds were protected using this PPG and then deprotected using visible or near-infrared light. The low cytotoxicity of NPIM suggests its potential application in physiological studies.
Due to cell damage caused by UV light, photoremovable protecting groups (PPGs) that are removed using visible or near-infrared light are attracting attention. A 2-(4-nitrophenyl)-1H-indolyl-3-methyl chromophore (NPIM) was synthesized as a novel PPG. Various compounds were caged using this PPG and uncaged using visible or near-infrared light. Low cytotoxicity of NPIM indicates that it may be applied in physiological studies.
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