Synthesis of Glycopolymers Carrying 3′-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E

One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).

Automated summary

One of the new strategies for treating autoimmune diseases is targeting the Siglec receptor, a membrane protein that can suppress immune responses. In this study, glycopolymers carrying 3'-sialyllactose were synthesized and evaluated for their immunosuppression ability using RAW 264.7 macrophages. The inhibition of signal transmission was found to be dependent on the density of glycounit and reached maximum at a moderate density (70%).