Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 242, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2021.105150
Keywords
Phloretin; Nanostructured lipid carrier; Antioxidant activity; Sustained release; Digestion behavior
Categories
Funding
- Science and Technology Achievements Transformation Projects of Jiangsu Province of China [BY2016076-10]
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Phloretin is a powerful antioxidant with various effects, but its low water solubility, absorption rate, and unstable properties limit its application. By designing a nanostructured lipid carrier, the stability and absorption of phloretin can be improved, making it a promising carrier in the food industry.
Phloretin is a powerful antioxidant with many effects, such as anti-cancer, anti-inflammatory, promoting cell renewal, delaying aging and so on. However, the application of phloretin was limited by its low water solubility, low absorption in vivo and unstable properties. A phloretin-loaded nanostructured lipid carrier was designed with a high-pressure homogenization technique. The mean particle size of phloretin NLC was 137.40 +/- 3.27 nm, and the Polydispersity index (PdI) value was 0.237 +/- 0.005. The encapsulation efficiency was 96.68% +/- 0.06%. Transmission electron microscopy images showed that the phloretin-loaded nanostructured lipid carriers were spherical. Phloretin in NLC showed a sustained release pattern in vitro. The results showed that phloretin NLC is more suitable for absorption than phloretin ethanol solution, and NLC can be a promising carrier for phloretin in the food industry.
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