Journal
CHEMISTRY & BIODIVERSITY
Volume 19, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202100990
Keywords
secondary metabolites; structural elucidation; cytotoxicity; antioxidant activity
Funding
- National Key R&D Program of China [2018YFC0311002]
- National Natural Science Foundation of China [32022002, 21772228, 21977113]
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Two new decalin derivatives, fusarielins O and P, were isolated from the crude extract of Talaromyces sp., along with seven known compounds. The structures of the new compounds were determined through comprehensive spectroscopic analyses. The compounds were evaluated for their cytotoxic and radical scavenging activities.
Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude extract of the marine-derived fungus Talaromyces sp. The planar structures of the new compounds were elucidated by comprehensive spectroscopic analyses of NMR and HR-ESI-MS. The absolute configuration of 1 was assigned by Snatzke's method and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-9 were evaluated for their cytotoxic activities against three tumor cell lines and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
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