Journal
CHEMIE INGENIEUR TECHNIK
Volume 94, Issue 3, Pages 356-364Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cite.202100143
Keywords
Colloidal stability; Cooling rate; Droplet crystallization; Melt emulsification; Particle shape
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Funding
- Projekt DEAL
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Emulsions with crystalline dispersed phase are commonly used in life sciences, but they are often unstable and their rheological behavior can change. These changes are possibly due to shape transformations of the crystallized droplets, which depend on the cooling rate during production and storage temperature.
Emulsions with crystalline dispersed phase are widely used formulations in life sciences. Unfortunately, these products often are unstable resulting in changes of their rheological behavior. These changes could be linked to shape transformations of crystallized droplets, depending on the cooling rate in their production and temperature of storage. In a thermo-optical method, shape changes were investigated in a broad range of constant cooling rates or cooling rate ramps close to industrial processes. Cooling at slow to moderate cooling rates (0.1-50 K min(-1)), as found in typical stirred vessel tanks, induced self-shaping of droplets during crystallization, which resulted in platelet-like particles and fibers, deviating greatly from the formerly spherical shape. In contrast, fast cooling as found in heat exchangers resulted in mostly spherical shapes less prone to recrystallization-induced instabilities.
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