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AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
TL Rizner et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2006)
Tibolone metabolism in human liver is catalyzed by 3α/3β-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
S Steckelbroeck et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Catalytic mechanism and substrate selectivity of aldo-keto reductases: Insights from structure-function studies of Candida tenuis xylose reductase
Regina Kratzer et al.
IUBMB LIFE (2006)
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex
T Petrova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity
O El-Kabbani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Localization and altered expression of AKR1C family members in human ovarian tissues
Q Ji et al.
MOLECULAR AND CELLULAR PROBES (2005)
Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas
S Fukumoto et al.
CLINICAL CANCER RESEARCH (2005)
Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women
K Blouin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20α-hydroxysteroid dehydrogenase
RP Piekorz et al.
MOLECULAR ENDOCRINOLOGY (2005)
Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: Potential antineoplastic agents that work independently of cyclooxygenase isozymes
DR Bauman et al.
MOLECULAR PHARMACOLOGY (2005)
Expression and activity of 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women
S Blanchette et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity -: Implications for steroid hormone metabolism and action
S Steckelbroeck et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structure-function of human 3α-hydroxysteroid dehydrogenases:: genes and proteins
TM Penning et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2004)
Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol
U Breyer-Pfaff et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2004)
Tibolone is metabolized by the 3α/3β-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily:: Inversion of stereospecificity with a Δ5(10)-3-ketosteroid
S Steckelbroeck et al.
MOLECULAR PHARMACOLOGY (2004)
Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma
MJ Lewis et al.
BMC CANCER (2004)
The roles of aldo-keto reductases in steroid hormone action
DR Bauman et al.
DRUG NEWS & PERSPECTIVES (2004)
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling
Q Ji et al.
CANCER RESEARCH (2004)
Altered expression of 3 α-hydroxy steroid dehydrogenases in human glaucomatous optic nerve head astrocytes
OA Agapova et al.
NEUROBIOLOGY OF DISEASE (2003)
Human 20α-hydroxysteroid dehydrogenase:: Crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
JF Couture et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Structure-function relationships in 3α-hydroxysteroid dehydrogenases:: a comparison of the rat and human isoforms
TM Penning et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)
Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells -: art. no. 9
JP Wiebe et al.
BMC CANCER (2003)
Selective and potent inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
Y Higaki et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2003)
Progesterone metabolism in human leukemic monoblast U937 cells
T Suzuki et al.
ENDOCRINE JOURNAL (2002)
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells
NT Palackal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Progesterone receptors - animal models and cell signalling in breast cancer - Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer
C Lanari et al.
BREAST CANCER RESEARCH (2002)