Batch reactor scale-up of the mixing-sensitive Bechamp reaction based on the heat pulse method

Knowledge and control of mixing in batch processes can prevent yield losses during scale-up. Therefore, in this study, a new heat-mixing model based ono the measurement of the heat distribution after an applied heat pulse, is proposed. The model was developed to predict mesomixing and support scaleup, scale-down, and design and optimisation of batch reactors. The proposed model considers the influences of rotational speed, stirrer type, solvent, stirrer-to-tank diameter, liquid-height-to-tank diameter, injection time, and pumping number. A strong correlation between the mixing time of the heat pulse method and the mass-transfer coefficient of the mixing-sensitive Bechamp reaction was observed. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

In this study, a new heat-mixing model based on heat distribution measurement after an applied heat pulse is proposed to predict mesomixing and support scale-up, scale-down, design, and optimization of batch reactors. The model considers various factors, and a strong correlation between the mixing time of the heat pulse method and the mass-transfer coefficient of the mixing-sensitive Bechamp reaction was observed.