A novel approach for synchronous transformation and extraction of psoralen from fig (Ficus carica L.) leaves based on polarity of different macroporous adsorption resins

In this study, using fig leaves as materials, strong acidic cation exchange resin of D072 with -SO3H functional group was selected as catalyst to promote the conversion of psoralenglucoside (PO) to psoralen (PSO), and the strong acidic cation exchange resin transformation method (SACERTM) was developed for efficient extraction of PSO from fig leaves. Under the optimized extraction conditions, the yield of PSO was 36.74 mg/g. The transformation efficiency of PO to PSO reached 70.41% using 2 g of D072 resin as catalyst. Then, PSO in fig extract was enriched efficiently by X-5 macroporous adsorption resin (MAR). After eluting with 14-fold of column volume of 70% ethanol at 0.64 BV/h of elution flow rate, the purity of PSO was 24.8-fold higher than before enrichment. The results show that SACERTM combined with MAR purification is an efficient method for extracting and enriching PSO from fig leaves.& nbsp;(c) 2021 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Automated summary

In this study, fig leaves were used as materials to efficiently extract and enrich psoralen (PSO) using a strong acidic cation exchange resin transformation method (SACERTM) combined with macroporous adsorption resin (MAR). The optimized extraction conditions yielded a high PSO yield of 36.74 mg/g, with a conversion efficiency of psoralenglucoside (PO) to PSO reaching 70.41% using D072 resin as a catalyst. After enrichment using MAR, the purity of PSO increased by 24.8-fold. This study demonstrates the effectiveness of SACERTM combined with MAR purification for extracting and enriching PSO from fig leaves.