Journal
CHEMICAL ENGINEERING JOURNAL
Volume 428, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.132607
Keywords
Gas-shearing fabrication; Core-shell multicompartmental microparticles; Mangosteen-like microparticles; Artificial cells; Enzymatic cascade reaction
Categories
Funding
- National Natural Science Foundation of China [21774060]
- Priority Academic Program Development of Jiangsu Higher Education In-stitutions (PAPD)
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)
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Core-shell multicompartmental microparticles resembling eukaryotic cells have been created using an oil-free gas-shearing fabrication method. The resulting mangosteen-like particles have segregated compartments, making them suitable for controlling enzymatic cascade reactions. This approach shows potential for applications like developing artificial pancreatic beta cells for insulin release.
Core-shell multicompartmental microparticles have gained increasing attention as their architecture resembles the multicompartmental composition of eukaryotic cells. However, challenges remain in the fabrication of biocompatible multicompartmental microparticles at a sufficiently high scale. Herein, all-aqueous 'mangosteenlike' core-shell multicompartmental microparticles were created by an oil-free gas-shearing fabrication approach. Both the shell thickness and core size of thus obtained mangosteen-like microparticles can be easily finetuned. Mangosteen-like particles have well segregated (up to eight) compartments which are attractive to precisely control enzymatic cascade reactions. To illustrate the application potential, insulin releasing mangosteen-like microparticles ('artificial pancreatic beta cells') were developed.
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