Journal
CHEMICAL ENGINEERING JOURNAL
Volume 438, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.135372
Keywords
Mitochondrial Calcium Overload; Cuprous oxide; Hydroxyl Radical; Full-Degradation; Chemodynamic Therapy
Categories
Funding
- National Natural Science of China [21788102, 51971116]
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Mitochondrial calcium ions (Ca2+) overload has been identified as a potential strategy for effective cancer treatment. Inspired by this, the researchers successfully developed a degradable nanocatalyst that can respond to the tumor microenvironment and generate toxic radicals to kill tumor cells. Both in vitro and in vivo evaluations demonstrated the efficient anti-tumor effect of this nanocatalyst.
Mitochondrial calcium ions (Ca2+) overload, an abnormal accumulation of free Ca2+ in mitochondrial, has become a potential strategy for effective cancer treatment. Inspired by mitochondrial Ca2+ overload-induced ROS generation, a tumor microenvironment (TME)-responded full-degradable ACC@Cu2O-TPP NCs are successfully fabricated for effective chemodynamic therapy (CDT) via toxic hydroxyl radical (center dot OH) bursting. The as-synthesized nanocatalysts are stable and safe in normal tissues but will quickly degrade into Ca2+ and cuprous ions (Cu+) under the acidic TME. The mitochondrial Ca2+ overload effectively simulates extra H2O2 generation. Then Cu+ catalyzes the produced H2O2 into toxic center dot OH to kill the tumor cells via Fenton-like reaction. Meanwhile, abundant GSH in tumor cells can further reduce Cu2+ into Cu+ to enhance the CDT effect. Both in vitro and in vivo evaluations demonstrate the efficient anti-tumor effect of ACC@Cu2O-TPP NCs via mitochondrial Ca2+ overload-induced center dot OH bursting. We believe that the development of ACC@Cu2O-TPP NCs will be an amazing inspiration for designing safe and green chemodynamic nanocatalysts for highly efficient cancer treatment.
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