Journal
CHEMICAL ENGINEERING JOURNAL
Volume 427, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.131841
Keywords
Microplastic; Nanoplastic; Long-term toxicity; Bioaccumulation; Induced Pluripotent Stem Cell; Developmental toxicology
Categories
Funding
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Ministry of Science and ICT of the Korean government [2016M3A9C6917402, 2016M3A9C6917405, 2019M3A9H110378611]
- Basic Science Research Program through the NRF [NRF-2017R1E1A1A01074343, 2020R1A4A1016093, 2021R1A2C1010865]
- National Research Foundation of Korea [2021R1A2C1010865] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study found that NPs can be internalized into cells within a short period of time, leading to significant growth inhibition of hiPSCs. However, the accumulated NPs did not have adverse effects on cell differentiation.
The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a longterm. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.
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