All in one theranostic nanoagent based on MoSe2/Au@PEG hollow nanospheres for the enhanced synergetic antitumor

MoSe2/Au@PEG nanoheterostructure were synthesized to integrate multi-imaging and therapeutic strategies into one nanoplatform. These Au nanoparticles were deposited on the surface of MoSe2 hollow nanospheres (250 nm) to reveal the enhanced NIR harvest owing to localized surface plasma resonance of Au, which could be varied with the particle sizes and the distance of Au nanoparticles. Therefore, MoSe2/Au@PEG nanocomposites revealed the great photothermal conversion efficiency to 73.0 %. In addition, they also exhibited the promoted reactive oxygen species (ROS) generation about 4-times as the pure sample, owing to the plasmon-mediated electron-transfer between the two components. Besides, the peroxidase and catalase activity of MoSe2 could convert the intracellular H2O2 to center dot OH and O2 for chemotherapy. In addition, the glucose oxidase activity of Au made the H2O2 supplement for promoted chemodynamic therapy (CDT) and the glucose consumption for starvation therapy. It noted that the MoSe2/Au@PEG heterostructure also increased the nanozyme activity (2 times), ascribing to the decreased resistant of the charge transfer. The photothermal/photodynamic/starvation therapy combined with CDT could bring the immunogenic cell death that was associated with anti-CTLA4 to further arouse immune response to eliminate the primary as well as metastatic tumors. In addition, the novel biodegradation of the nanocomposite made the elimination via urine and feces within 18 d.

Automated summary

The MoSe2/Au@PEG nanoheterostructure combines imaging and therapeutic strategies, exhibiting enhanced photothermal conversion efficiency and ROS generation. It also increases nanozyme activity, potentially promoting cell death and immune response.