Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors

We report a modular approach in which a noncovalently cross-linked single chain nanoparticle (SCNP) selectively binds catalyst cofactors and substrates to increase both the catalytic activity of a Cu-catalyzed alkyne-azide cycloaddition reaction and the Ru-catalyzed cleavage of allylcarbamate groups compared to the free catalysts.

Automated summary

The research presents a modular approach utilizing noncovalently cross-linked single chain nanoparticles (SCNP) to selectively bind catalyst cofactors and substrates, resulting in increased catalytic activity in Cu-catalyzed alkyne-azide cycloaddition reaction and Ru-catalyzed cleavage of allylcarbamate groups compared to free catalysts.