Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 11, Pages 1760-1763Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05270e
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21735003, 21605098]
- Award for Team Leader Program of Taishan Scholars of Shandong Province, China
Ask authors/readers for more resources
Mismatched fluorescent probes are designed to directly monitor long noncoding RNA (lncRNA) in living cells, with enhanced strand displacement reaction rate towards the target lncRNA. These probes can monitor intracellular lncRNA expression levels in various cell lines and discriminate cancer cells from normal cells, holding great potential in fundamental biomedical research and clinical disease diagnosis.
We design mismatched fluorescent probes to directly monitor the long noncoding RNA (lncRNA) in living cells. The introduction of mismatched bases in the fluorescent probe greatly enhances the strand displacement reaction rate toward the target lncRNA. These mismatched probes can monitor the intracellular lncRNA expression level in various cell lines and discriminate cancer cells from normal cells, holding great potential in fundamental biomedical research and clinical disease diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available