Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 23, Pages 3831-3834Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc00840h
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- CSIR, India [02(0416)/21/EMR-II]
- CSIR, New Delhi
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Here, we report a method for the cerium-mediated decarboxylative alkylation of quinoxalin-2(1H)-ones using feedstock carboxylic acids as a radical precursor via photoinduced-LMCT. This operationally simple protocol overcomes the limitation of direct use of carboxylic acids and allows for the synthesis of the desired alkylated heterocyclic product in good to excellent yields.
Here, we report the cerium-mediated decarboxylative alkylation of quinoxalin-2(1H)-ones utilizing feedstock carboxylic acids as a radical precursor via photoinduced-LMCT. This operationally simple protocol overcomes the limitation of the direct use of carboxylic acids to access alkyl radicals. Spectroscopic investigations reveal the photoinduced LMCT and CO2 evolving events. We have utilized a broad range of alkyl carboxylic acids (1 degrees to 3 degrees acids), amino acids and pharmaceutically-important acids as a coupling partner to synthesise the desired alkylated heterocyclic product in good to excellent yields.
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