4.7 Article

Red-emitting fluorogenic BODIPY-tetrazine probes for biological imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 58, Issue 2, Pages 298-301

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05863k

Keywords

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Funding

  1. National Natural Science Foundation of China [21572125]
  2. Fundamental Research Funds for the Central Universities of China [GK201703023]
  3. Guizhou Science and Technology Department of China [[2020]4Y206, [2020]1Y395]
  4. Guizhou Medical University [J[2021]047]
  5. Shaanxi Normal University

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A series of new BODIPY-tetrazine derivatives have been developed with a twist intramolecular charge transfer state, among which, the derivative 6i is stable with excellent red emission performance and has been successfully used to image trans-cyclooctene-labeled lipids in mammalian cells and cyclopropene-labeled sugars in cancer cells under no-wash conditions.
A series of new BODIPY-tetrazine derivatives have been developed with a twist intramolecular charge transfer (TICT) state in polar solvents, which is an electron transfer process that occurs upon photoexcitation in a molecule that usually consists of an electron donor and acceptor linked by a single bond. Among them, the BODIPY-tetrazine derivative 6i was stable towards long-term storage and red-emitting with excellent performance, and was further used to image trans-cyclooctene-labeled lipids in mammalian cells and cyclopropene-labeled sugars in cancer cells under no-wash conditions.

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