Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 21, Pages 3525-3528Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc00169a
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Funding
- National Natural Science Foundation of China [21971112]
- Guizhou University
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This study presents a cascade method for the synthesis of beta-aminoketones through the reductive hydroamination of alkynes under mild metal-free conditions. The method offers a rapid and diverse approach for the synthesis of drug molecules with the beta-aminoketone skeleton.
This study describes a cascade method for the synthesis of beta-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding beta-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the beta-aminoketone skeleton.
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