Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 5, Pages 633-636Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05718a
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Funding
- National Natural Science Foundation of China [31770384, 21605164]
- Huayi Technology Innovation Center for Research Resources [HTIC P01 RR2017001A]
- Youth Elite Project of National Ethnic Affairs Commission of P. R. China [10301-0190040110]
- Double World-First Class Development Program of MUC [Yldxxk201819]
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Michler's ethylketone (MEK) has been successfully optimized as a novel matrix for the enhancement of lipid detection and imaging in tissues by MALDI-MSI. Its properties as a powerful MALDI matrix include strong UV absorption, mu m-sized crystals, uniform matrix-coating, super high vacuum chemical stability, low matrix-related ion interference, super soft ionization, and high lipid ionization efficiency.
Michler's ethylketone (MEK, 4,4 '-bis(diethylamino)benzophenone), commonly-known as an intermediate in the synthesis of dyes and pigments, was successfully screened and optimized as a novel matrix for the enhancement of lipid in situ detection and imaging in tissues by MALDI-MSI. The results show several properties of MEK as a powerful MALDI matrix, including strong UV absorption, mu m-sized crystals and uniform matrix-coating, super high vacuum chemical stability, low matrix-related ion interference, super soft ionization, and high lipid ionization efficiency.
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