Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones

The asymmetric hydrogenation of fluorinated olefins is an efficient pathway towards the synthesis of chiral fluorine-containing compounds. This paper described metal-free asymmetric hydrogenation of 3-fluorinated chromones with the use of readily available achiral borane and chiral oxazoline as an FLP catalyst for the first time. A variety of optically active 3-fluorochroman-4-ones were obtained in high yields with up to 88% ee.

Automated summary

This study demonstrated the metal-free asymmetric hydrogenation of 3-fluorinated chromones using achiral borane and chiral oxazoline as an FLP catalyst, resulting in the synthesis of a variety of optically active 3-fluorochroman-4-ones with high yields of up to 88% ee.