Room-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand

We report the room-temperature Pd-catalyzed methoxy-carbonylation with high branched selectivity using a new class of bisphosphine-picolinamide ligands. Systematic optimization of ligand structures and reaction conditions revealed the significance of both the picolinamide and bisphosphine groups in the ligand backbone. This strategic design of ligand was leveraged to deliver various alpha-substituted acrylates in good to excellent yields.

Automated summary

Through systematic optimization of ligand structures and reaction conditions, we successfully report a room-temperature Pd-catalyzed methoxy-carbonylation with high branched selectivity. The strategic design of the new class of bisphosphine-picolinamide ligands enabled the synthesis of various alpha-substituted acrylates in good to excellent yields.