Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 7, Pages 949-952Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05204g
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Funding
- Beijing Nova Program [Z201100006820049]
- National Natural Science Foundation of China [21907109]
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A series of naphthalimide-tetrazines were developed as bioorthogonal fluorogenic probes, which showed significant fluorescence enhancement, notable aggregation-induced emission (AIE) characters, and multicolor emissions after reacting with strained dienophiles. Manipulation of the pi-bridge in the fluorophore skeleton allows for fine-tuning of emission wavelength and impacts AIE-active properties. These probes enabled successful no-wash fluorogenic protein labeling and mitochondria-selective bioorthogonal imaging in live cells.
A series of naphthalimide-tetrazines were developed as bioorthogonal fluorogenic probes, which could produce significant fluorescence enhancement, notable aggregation-induced emission (AIE) characters and multicolor emissions after bioorthogonal reaction with strained dienophiles. Manipulating the pi-bridge in the fluorophore skeleton allows fine-tuning of the emission wavelength and influences the AIE-active properties. With these probes, we succeeded in no-wash fluorogenic protein labeling and mitochondria-selective bioorthogonal imaging in live cells.
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