A novel facile one-pot synthesis of photothermally responsive carbon polymer dots as promising drug nanocarriers

Luminescent and photothermic carbon polymer dots (CPDs-PNM), composed of a carbonized core and cross-linked chains of poly(N-isopropylacrylamide), were synthetized by a novel, simple, solvent- and reagent-free method. The formation of CPDs-PNM was controlled by both temperature and heating time. The CPDs-PNM exhibited LCST behaviour, high photothermal conversion efficiency, curcumin loading capacity and no toxicity to eukaryotic cells. Proof of concept experiments confirmed an excellent thermally induced drug release activity to be used for photothermally controlled drug release.

Automated summary

In this study, luminescent and photothermic carbon polymer dots were synthesized using a novel, simple, solvent- and reagent-free method. The formation of these dots was controlled by temperature and heating time, and they exhibited excellent photothermal conversion efficiency and drug release activity.