Stable high-oxidation-state complex in situ Mn(v)-Mn(iii) transition to achieve highly efficient cervical cancer therapy

Designing metal complexes to target the vulnerable redox balance in cancer cells is a promising strategy to realize successful cancer therapy. The synthesized stable nitridomanganese(v) complex Mn-V(N) (salen) not only reacts with GSH to achieve in situ Mn(v)-Mn(iii) transformation to down-regulate the antioxidant system, but also catalyzes H2O2 to higher oxidation capacity ROS to up-regulate the intracellular oxidative level, finally resulting in cancer cell death.

Automated summary

Designing metal complexes to target the redox balance in cancer cells is a promising strategy for successful cancer therapy. The synthesized stable nitridomanganese(V) complex can down-regulate the antioxidant system by reacting with GSH and up-regulate the intracellular oxidative level by catalyzing H2O2, leading to cancer cell death.