Journal
CHEMBIOCHEM
Volume 23, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100678
Keywords
aggregation; amyloids; diabetes; inhibitors; insulin
Funding
- Science and Engineering Research Board [EMR/2016/004575]
- J.C. Bose Fellowship, SERB
- Tata Innovation Fellowship of the Department of Biotechnology [BT/HRD/35/01/01/2017]
- DST [DST/INSPIRE/04/2019/002454]
- MHRD
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This review discusses the methods for decelerating insulin aggregation, including excipient additions and intrinsic modifications to enhance its stability and usage.
The discovery of insulin came with very high hopes for diabetic patients. In 2021, the world celebrated the 100th anniversary of the discovery of this vital hormone. However, external use of insulin is highly affected by its aggregating tendency that occurs during its manufacturing, transportation, and improper handling which ultimately leads to its pharmaceutically and biologically ineffective form. In this review, we aim to discuss the various approaches used for decelerating insulin aggregation which results in the enhancement of its overall structural stability and usage. The approaches that are discussed are broadly classified as either a measure through excipient additions or by intrinsic modifications in the insulin native structure.
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