Journal
CHEMBIOCHEM
Volume 23, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100464
Keywords
-
Funding
- Industrial Biotechnology Innovation Centre (IBioIC) from Prozomix Ltd.
- Biotechnology and Biological Sciences Research Council (BBSRC) from Prozomix Ltd.
- Industrial Affiliates of CoEBio3
- ERC [742987]
- ARAID Foundation [E07_20R]
- Agencia Estatal de Investigacion [PID2020-113351RA-100/AEI/10.13039/501100011033]
Ask authors/readers for more resources
Organic chemistry provides society with essential products, but concerns about the environmental impact of the chemical industry are driving changes in manufacturing. Biocatalysis, using enzymes as catalysts, offers a sustainable alternative with high selectivity and mild reaction conditions. Advances in molecular biology, bioinformatics, and chemical engineering have expanded the range of available transformations in biocatalysis.
Organic chemistry provides society with fundamental products we use daily. Concerns about the impact that the chemical industry has over the environment is propelling major changes in the way we manufacture chemicals. Biocatalysis offers an alternative to other synthetic approaches as it employs enzymes, Nature's catalysts, to carry out chemical transformations. Enzymes are biodegradable, come from renewable sources, operate under mild reaction conditions, and display high selectivities in the processes they catalyse. As a highly multidisciplinary field, biocatalysis benefits from advances in different areas, and developments in the fields of molecular biology, bioinformatics, and chemical engineering have accelerated the extension of the range of available transformations (E. L. Bell et al., Nat. Rev. Meth. Prim. 2021, 1, 1-21). Recently, we surveyed advances in the expansion of the scope of biocatalysis via enzyme discovery and protein engineering (J. R. Marshall et al., Tetrahedron 2021, 82, 131926). Herein, we focus on novel enzymes currently available to the broad synthetic community for the construction of new C-C, C-N and C-O bonds, with the purpose of providing the non-specialist with new and alternative tools for chiral and sustainable chemical synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available