Journal
CHEMBIOCHEM
Volume 23, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100423
Keywords
@VUMC_ID; @VICB_Vanderbilt; @Townsend_Lab; bacterial pathogenesis; glycobiology; Group B Streptococcus; human milk oligosaccharides; Streptococcus agalactiae
Funding
- National Institutes of Health [NICHD R01 HD090061]
- Office of Medical Research, Department of Veterans Affairs [I01BX005352-01]
- National Science Foundation [1847804]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1847804] Funding Source: National Science Foundation
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Group B Streptococcus (GBS) is a pathogen causing severe perinatal infections, but human milk oligosaccharides (HMOs) have antimicrobial effects against GBS and can enhance antibiotic activity against this bacterium.
Streptococcus agalactiae or Group B Streptococcus (GBS) is a Gram-positive bacterial pathobiont that is the etiological cause of severe perinatal infections. GBS can colonize the vagina of pregnant patients and invade tissues causing ascending infections of the gravid reproductive tract that lead to adverse outcomes including preterm birth, neonatal sepsis, and maternal or fetal demise. Additionally, transmission of GBS during labor or breastfeeding can also cause invasive infections of neonates and infants. However, human milk has also been shown to have protective effects against infection; a characteristic that is likely derived from antimicrobial and immunomodulatory properties of molecules that comprise human milk. Recent evidence suggests that human milk oligosaccharides (HMOs), short-chain sugars that comprise 8-20 % of breast milk, have antimicrobial and anti-biofilm activity against GBS and other bacterial pathogens. Additionally, HMOs have been shown to potentiate the activity of antibiotics against GBS. This review presents the most recent published work that studies the interaction between HMOs and GBS.
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