Journal
CEREBRAL CORTEX
Volume 32, Issue 20, Pages 4397-4421Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab491
Keywords
demyelination; epilepsy; HCN channels; SWDs; thalamocortical dysrhythmia
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Funding
- Deutsche Forschungsgemeinschaft [RTG2515-1, SFB-TR 128-B06, SFB-TR 128-B07, BU1019/16-1]
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There is no consensus on the exact prevalence of epileptic seizures or epilepsy in multiple sclerosis (MS). This study used a mouse model to investigate the relationship between epileptic activity, loss of myelin, and pro-inflammatory cytokines. The findings suggest that demyelination-related changes in thalamic inward current may contribute to the prevalence of seizures in MS.
A consensus is yet to be reached regarding the exact prevalence of epileptic seizures or epilepsy in multiple sclerosis (MS). In addition, the underlying pathophysiological basis of the reciprocal interaction among neuroinflammation, demyelination, and epilepsy remains unclear. Therefore, a better understanding of cellular and network mechanisms linking these pathologies is needed. Cuprizone-induced general demyelination in rodents is a valuable model for studying MS pathologies. Here, we studied the relationship among epileptic activity, loss of myelin, and pro-inflammatory cytokines by inducing acute, generalized demyelination in a genetic mouse model of human absence epilepsy, C3H/HeJ mice. Both cellular and network mechanisms were studied using in vivo and in vitro electrophysiological techniques. We found that acute, generalized demyelination in C3H/HeJ mice resulted in a lower number of spike-wave discharges, increased cortical theta oscillations, and reduction of slow rhythmic intrathalamic burst activity. In addition, generalized demyelination resulted in a significant reduction in the amplitude of the hyperpolarization-activated inward current (I-h) in thalamic relay cells, which was accompanied by lower surface expression of hyperpolarization-activated, cyclic nucleotide-gated channels, and the phosphorylated form of TRIP8b (pS237-TRIP8b). We suggest that demyelination-related changes in thalamic I-h may be one of the factors defining the prevalence of seizures in MS.
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