Journal
CEREBELLUM
Volume 21, Issue 6, Pages 1029-1051Publisher
SPRINGER
DOI: 10.1007/s12311-021-01335-7
Keywords
Essential tremor; Magnetic resonance imaging; Grey matter; White matter; MRI functional; Systematic review
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This systematic review highlights the role of MRI in identifying the structural abnormalities associated with motor and non-motor symptoms in essential tremor (ET), particularly focusing on cerebellar damage and connectivity alterations between the cerebellum and various cortical areas. Many studies found an association between MRI findings and non-motor symptoms in ET patients.
Essential tremor (ET) is one of the most common movement disorders. Over the last 10 years, magnetic resonance imaging (MRI) has shed light on the structural and functional abnormalities possibly involved in ET pathophysiology. In this systematic review, we aimed to identify the cortical and subcortical structures involved and the role that different brain areas play in the pathophysiology of motor and non-motor ET features. We found that structural (grey and white matter) cerebellar damage and connectivity alterations between the cerebellum and various cortical areas play a role in both motor and non-motor symptoms of ET. In particular, many studies found an association between MRI findings and non-motor symptoms.
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