Journal
CEPHALALGIA
Volume 42, Issue 8, Pages 804-809Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/03331024211068074
Keywords
Headache disorders; secondary; COVID-19; post-COVID; migraine
Categories
Funding
- regional health administration (Gerencia Regional de Salud (GRS) Castilla y Leon) [2289/A/2020]
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The duration of headache during the acute phase of COVID-19 is 2 weeks, but approximately a fifth of patients experience persistent headache following a chronic daily pattern.
Background Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19. Methods This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up. Results We included 905 patients. Their median age was 51 (IQR 45-65), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6-39) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5-21.8%) and after 9 months in 16.0% (95% confidence interval: 13.7-18.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582-0.737). Conclusion The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.
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