Roles of SIRT6 in kidney disease: a novel therapeutic target

SIRT6 is an NAD(+) dependent deacetylase that belongs to the mammalian sirtuin family. SIRT6 is mainly located in the nucleus and regulates chromatin remodeling, genome stability, and gene transcription. SIRT6 extensively participates in various physiological activities such as DNA repair, energy metabolism, oxidative stress, inflammation, and fibrosis. In recent years, the role of epigenetics such as acetylation modification in renal disease has gradually received widespread attention. SIRT6 reduces oxidative stress, inflammation, and renal fibrosis, which is of great importance in maintaining cellular homeostasis and delaying the chronic progression of kidney disease. Here, we review the structure and biological function of SIRT6 and summarize the regulatory mechanisms of SIRT6 in kidney disease. Moreover, the role of SIRT6 as a potential therapeutic target for the progression of kidney disease will be discussed. [GRAPHICS] .

Automated summary

SIRT6 is a crucial NAD(+) dependent deacetylase primarily located in the nucleus, regulating various physiological activities such as DNA repair, energy metabolism, oxidative stress, inflammation, and fibrosis. In the context of kidney disease, SIRT6 plays a vital role in maintaining cellular homeostasis and delaying disease progression.