Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 78, Issue 24, Pages 8097-8108Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-021-04016-0
Keywords
Glycolysis; Oxidative phosphorylation; pH; Oxygen; Nutrient; Insulin
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Funding
- University of Macau [MYRG2018-00135-FHS, MYRG2019-00147-FHS]
- Science and Technology Development Fund, Macau SAR [0059/2019/A1, 0123/2019/A3, 0011/2019/AKP]
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Energy metabolism is crucial for cell survival, proliferation, pluripotency, and cell fate determination in human pluripotent stem cells. Understanding the key factors influencing energy metabolism is important for cellular regulation and stem cell applications.
All living organisms need energy to carry out their essential functions. The importance of energy metabolism is increasingly recognized in human pluripotent stem cells. Energy production is not only essential for cell survival and proliferation, but also critical for pluripotency and cell fate determination. Thus, energy metabolism is an important target in cellular regulation and stem cell applications. In this review, we will discuss key factors that influence energy metabolism and their association with stem cell functions.
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