Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 78, Issue 24, Pages 8001-8047Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-021-04004-4
Keywords
Neurotoxicity; Neurological diseases; Neuroinflammation; Micro RNAs; Long non-coding RNAs; NF-kappa B; VEGFR2; Ubiquitin proteasome system; ER stress; Flavonoid; Flavones; Flavanones
Categories
Ask authors/readers for more resources
Autophagy and apoptosis are two essential self-destructive processes that regulate cellular homeostasis through signal transduction mechanisms, playing crucial roles in various diseases including neurodegenerative diseases and cancer. These cell death pathways share common molecular mechanisms, with some key signaling molecules triggering apoptotic and autophagic processes in cells.
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular homeostasis, which are characterized by their morphology and regulated through signal transduction mechanisms. These pathways determine the fate of cellular organelle and protein involved in human health and disease such as neurodegeneration, cancer, and cardiovascular disease. Cell death pathways share common molecular mechanisms, such as mitochondrial dysfunction, oxidative stress, calcium ion concentration, reactive oxygen species, and endoplasmic reticulum stress. Some key signaling molecules such as p53 and VEGF mediated angiogenic pathway exhibit cellular and molecular responses resulting in the triggering of apoptotic and autophagic pathways. Herein, based on previous studies, we describe the intricate relation between cell death pathways through their common genes and the role of various stress-causing agents. Further, extensive research on autophagy and apoptotic machinery excavates the implementation of selective biomarkers, for instance, mTOR, Bcl-2, BH3 family members, caspases, AMPK, PI3K/Akt/GSK3 beta, and p38/JNK/MAPK, in the pathogenesis and progression of neurodegenerative diseases. This molecular phenomenon will lead to the discovery of possible therapeutic biomolecules as a pharmacological intervention that are involved in the modulation of apoptosis and autophagy pathways. Moreover, we describe the potential role of micro-RNAs, long non-coding RNAs, and biomolecules as therapeutic agents that regulate cell death machinery to treat neurodegenerative diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available