Caught in the antiviral crossfire Ganciclovir-associated mutagenesis in HSC transplant recipients

Article Multidisciplinary Sciences

Somatic mutation landscapes at single-molecule resolution

Federico Abascal et al.

Summary: The study developed a method to detect mutations in single cells or small clones, revealing that somatic mutations also occur in non-dividing cells and contribute significantly to somatic mutagenesis.

NATURE (2021)

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Article Multidisciplinary Sciences

Lineage tracing of human development through somatic mutations

Michael Spencer Chapman et al.

Summary: By reconstructing a phylogenetic tree of blood development in healthy human fetuses, it was found that individual haematopoietic progenitors acquire multiple somatic mutations by 18 weeks after conception. The data also support a hypoblast origin of the extra-embryonic mesoderm and primitive blood in humans.

NATURE (2021)

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Article Cell & Tissue Engineering

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

Jurrian K. de Kanter et al.

Summary: The majority of transplanted HSPCs did not show altered mutation accumulation post-transplantation, but in some recipients, multiple HSPCs exhibited an increased mutation burden. This increase was attributed to a unique mutational signature caused by antiviral drug ganciclovir, which may contribute to therapy-related carcinogenesis in transplant recipients.

CELL STEM CELL (2021)

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Article Multidisciplinary Sciences