Into the multiverse of gene edited NK cell-based therapeutic strategies

In this issue of Cell Stem Cell, Woan et al., (2021) investigate the anti-cancer activity of triple gene edited iPSC-derived natural killer (NK) cells and demonstrate that expression of a modified CD16a and interleukin (IL)-15 receptor combined with knockout of CD38 improves NK cell-mediated activity against leukemia and multiple myeloma.

Automated summary

The study demonstrates that expression of modified CD16a and IL-15 receptor combined with knockout of CD38 can enhance NK cell-mediated activity against leukemia and multiple myeloma.