Journal
CELL RESEARCH
Volume 32, Issue 2, Pages 111-112Publisher
SPRINGERNATURE
DOI: 10.1038/s41422-021-00579-6
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This review discusses a study by Li et al. on the complex mechanism of autophagosome biogenesis, focusing on a new type of ERGIC-ERES membrane contact. The study attempts to reconcile their findings with the proposal that the recycling endosome is a core platform for autophagosome biogenesis.
Autophagosome biogenesis occurs via a complex mechanism that involves membranes from different subcellular compartments. Here, we review an elegant study from Li et al. describing a new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that leads to the formation of COPII-coated vesicles essential for the formation of the autophagosome, and attempt to reconcile their findings with our studies proposing that the recycling endosome is a core platform for autophagosome biogenesis.
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