Journal
CELL METABOLISM
Volume 34, Issue 2, Pages 189-191Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2022.01.003
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- JDRF
- German Research Foundation (DFG)
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The study identifies olfactory receptor Olfr109 in beta cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet inflammation, beta cell failure, and diabetes progression.
In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in beta cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet inflammation, beta cell failure, and diabetes progression.
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