Why does obesity cause diabetes?

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in b cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.

Automated summary

The accumulation of excessive body fat can lead to type 2 diabetes, and the risk of type 2 diabetes increases with an increase in body mass index. The global increase in obesity has therefore resulted in a corresponding increase in the prevalence of type 2 diabetes. The mechanisms linking obesity and type 2 diabetes involve complex changes in b cell function, adipose tissue biology, and multi-organ insulin resistance, which can be improved or even normalized through weight loss.