4.3 Article

Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement

Daniela Haase et al.

Summary: The study found significant and reversible changes in circulating metabolites of patients with AS. Some metabolites showed strong correlations with clinical parameters, supporting the use of these data to identify novel diagnostic and prognostic markers for disease screening, pathophysiological studies, and patient surveillance.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

Article Veterinary Sciences

Andrographolide attenuates inflammatory response induced by LPS via activating Nrf2 signaling pathway in bovine endometrial epithelial cells

Kaiqiang Fu et al.

Summary: Andrographolide exhibits significant anti-inflammatory effects in the LPS-induced inflammatory response of bEECs by reducing the production of inflammatory factors through the activation of Nrf2.

RESEARCH IN VETERINARY SCIENCE (2021)

Review Cardiac & Cardiovascular Systems

Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease

Katherine Driscoll et al.

Summary: Calcific aortic valve disease is on the rise globally, but treatment is limited to prosthetic replacement. With a growing number of younger and more active patients, alternative therapies are needed. There is potential for biologically based diagnostics and treatments to help alleviate or delay disease progression, but a limited understanding of the disease mechanisms hinders progress towards clinical interventions.

CIRCULATION RESEARCH (2021)

Review Cardiac & Cardiovascular Systems

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis

Mark C. Blaser et al.

Summary: Calcific aortic valve disease is expected to almost triple in prevalence over the next 3 decades and currently lacks effective pharmacotherapy to halt its progression. Invasive aortic valve replacement remains the only treatment option, highlighting a substantial gap in care due to limited understanding of disease mechanisms and complex valvular microenvironment. Multiomics approaches, single-cell resolution studies, and systems biology strategies hold promise in shedding new light on valvular disease pathogenesis and identifying potential drug targets.

CIRCULATION RESEARCH (2021)

Article Biochemistry & Molecular Biology

Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in Relation to Cardiovascular Disease Risk

Moritz Warmbrunn et al.

Summary: The study identified distinct plasma metabolite profiles between insulin-resistant and non-insulin resistant subjects with metabolic syndrome. Despite insulin resistance being considered a risk factor for cardiovascular diseases, there was little correspondence between metabolites associated with insulin resistance and those associated with cardiovascular disease risk. Insulin resistance was related to fatty acid metabolism and glycerolphosphorylcholine.

METABOLITES (2021)

Article Rheumatology

Targeted metabolomic profiling and prediction of cardiovascular events: a prospective study of patients with psoriatic arthritis and psoriasis

Keith Colaco et al.

Summary: Novel metabolites associated with cardiovascular events in patients with psoriatic disease were identified, potentially improving cardiovascular risk prediction beyond traditional risk factors and the Framingham Risk Score. Further research on the causal role of these metabolites may clarify pathways leading to cardiovascular events in this population.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Biochemistry & Molecular Biology

Andrographolide: Regulating the Master Regulator NF-κB

K. P. Mishra

Summary: Natural product based medicines have been used in India since ancient times, with compounds like andrographolide being effective in treating inflammatory disorders by inhibiting the binding of the NF-kappa B transcription factor. NF-kappa B is a master regulator of proinflammatory gene expression, making andrographolide a key regulator in inflammation control.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2021)

Article Medicine, Research & Experimental

The natural compound andrographolide inhibits human aortic valve interstitial cell calcification via the NF-kappa B/Akt/ERK pathway

Yuming Huang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Pharmacology & Pharmacy

Calcific Aortic Valve Disease-Natural History and Future Therapeutic Strategies

Brunilda Alushi et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Cardiac & Cardiovascular Systems

The lipid theory in the pathogenesis of calcific aortic stenosis

V. Parisi et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2015)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)