Journal
CELL BIOLOGY AND TOXICOLOGY
Volume 39, Issue 1, Pages 217-236Publisher
SPRINGER
DOI: 10.1007/s10565-021-09656-3
Keywords
Angiogenesis; bOLED; hADSC; Phototoxicity; Stem cell therapy
Categories
Ask authors/readers for more resources
Low-level light therapy (LLLT) is a safe and noninvasive treatment method. Research has shown that using blue organic light-emitting diode (bOLED) can enhance the angiogenic properties of human adipose-derived stem cells (hADSC). This opens up new possibilities for the application of blue light in LLLT.
Low-level light therapy (LLLT) is a safe and noninvasive technique that has drawn attention as a new therapeutic method to treat various diseases. However, little is known so far about the effect of blue light for LLLT due to the generation of reactive oxygen species (ROS) that can cause cell damage. We introduced a blue organic light-emitting diode (bOLED) as a safe and effective light source that could generate a low amount of heat and luminance compared to conventional light sources (e.g., light-emitting diodes). We compared phototoxicity of bOLED light with different light fluences to human adipose-derived stem cells (hADSC). We further explored molecular mechanisms involved in the therapeutic efficacy of bOLED for enhancing angiogenic properties of hADSC, including intracellular ROS control in hADSCs. Using optimum conditions of bOLED light proposed in this study, photobiomodulation and angiogenic properties of hADSCs were enhanced. These findings might open new methods for using blue light in LLLT. Such methods can be implemented in future treatments for ischemic disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available