One ring doesn't rule them all: Distinct nuclear pore complexes in a single cell

Determining the structural plasticity and dynamics of nuclear pore complexes (NPCs) are major challenges. In this issue of Cell, Akey et al. present comprehensive NPC structures from in vitro and in vivo preparations, demonstrating multiple NPC forms in single cells while providing insight into the evolutionary origin of NPC architecture.

Automated summary

In this study, Akey et al. present comprehensive structures of nuclear pore complexes (NPCs) using in vitro and in vivo preparations. They demonstrate the existence of multiple NPC forms within a single cell and provide insights into the evolutionary origin of NPC architecture.