Journal
CELL
Volume 185, Issue 7, Pages 1117-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2022.02.014
Keywords
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Funding
- National Natural Science Foundation of Outstanding Youth Fund in China (NSFC) [31922081]
- Fundamental Research Funds for the Central Universities [Y0201900459]
- Bioinformatics Center (BIC) of Nanjing Agricultural University
- National Key Research and Development Program of China [2021YFD1801101]
- Shenzhen Science and Technology Program [KQTD20200820145822023]
- Guangdong Province Pearl River Talent Plan Innovation and Entrepreneurship Team Project [2019ZT08Y464]
- Health and Medical Research Fund [COVID190206]
- Australian Research Council Australia Laureate Fellowship [FL170100022]
- Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen) [G051322N, G0D5117N, G0B9317N]
- European Research Council under the European Union [725422-ReservoirDOCS]
- Wellcome Trust [206298/Z/17/Z]
- NIH [R01 AI153044]
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This study conducted a transcriptomic analysis of game animals in China and identified numerous potentially high-risk viruses for humans and domestic animals. Civets were found to carry the highest number of these high-risk viruses. The study also revealed the transmission pathways of coronaviruses between different species.
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of bat-associated coronavirus from bats to civets, as well as cross -species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
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