Transcription phenotype of circulating tumor cells in non-metastatic breast cancer

The presented research is relevant, as breast cancer is the most commonly diagnosed cancer in the female population worldwide, with the exception of skin cancer. The aim of this article is to study the transcription phenotype of circulating tumor cells in non-metastatic breast cancer. The transcriptional phenotype of circulating tumor cells (CTCs) was studied using real-time polymerase chain reaction (PCR). Three-year OS was 79.2, and 90.8 without the expression with p Log-Rank = 0.04. Independent prognostic factors for the recurrence of disease include the presence of CTCs expressing BIRC5 genes and ABC transporter genes in the peripheral blood before the start of special treatment for resectable breast cancer, as well as the preservation of CTCs per se after completion of special anticancer therapy. In patients with breast cancer stage I-IIIC, circulating tumor cells before special treatment have significant heterogeneity, manifested by a different transcriptional phenotype, including both actively growing and stem tumor cells, and cells at the epithelial-to-mesenchymal transition. The study of peripheral blood for the presence of CTCs during adjuvant antitumor therapy of breast cancer can serve as a reliable marker of the treatment efficacy.

Automated summary

This study demonstrates the impact of transcription phenotype of circulating tumor cells on prognosis in non-metastatic breast cancer, which can contribute to improving the treatment efficacy of breast cancer.