4.6 Article

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Three-finger proteins from snakes and humans acting on nicotinic receptors: Old and new

Victor I. Tsetlin et al.

Summary: This review focuses on the interactions of snake venom TFPs and Ly6/uPAR family proteins from mammals with nicotinic acetylcholine receptors (nAChRs), highlighting the different characteristics of various toxins and their interactions with different receptor subtypes.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Medicine, Research & Experimental

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

Josefa Dela Cruz Chuh et al.

Summary: Early success with brentuximab vedotin in treating classical Hodgkin lymphoma led to the development of multiple MMAE antibody-drug conjugates, but most of these have not been successful in clinical trials. This study describes the development of second-generation therapeutic ADCs targeting Ly6E, with a focus on using DNA-damaging agents to improve durability of response. The new ADCs showed promising preclinical efficacy in driving tumor regression and reducing the likelihood of resistance compared to traditional MMAE-based conjugates.
Review Biochemistry & Molecular Biology

Biochemistry of nicotine metabolism and its relevance to lung cancer

Sharon E. Murphy

Summary: Nicotine is the main addictive component of tobacco, and its metabolism plays a crucial role in smoking behavior and dose. Understanding nicotine biotransformation, particularly the role of enzymes like cytochrome P450 2A6, can help identify individuals at higher risk for tobacco-related diseases such as lung cancer.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Cell Biology

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain

Dmitrii Kulbatskii et al.

Summary: Lypd6 is a GPI-tethered protein in the Ly-6/uPAR family that enhances Wnt/beta-catenin signaling and has been suggested to affect nicotinic acetylcholine receptors (nAChRs). The recombinant water-soluble variant of Lypd6 inhibits ACh-evoked currents at α3β4- and α7-nAChRs, and can also suppress long-term potentiation in mouse hippocampal slices. Colocalization of Lypd6 with nAChRs was observed in primary cortical and hippocampal neurons, indicating its role in cholinergic system regulation in the brain.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Respiratory System

CHRNA5 rs16969968 polymorphism is associated with lung cancer risk: A meta-analysis

Wei Zhou et al.

CLINICAL RESPIRATORY JOURNAL (2020)

Letter Multidisciplinary Sciences

Inhaled nicotine and lung cancer: Potential role of the nicotinic acetylcholine receptor

R. P. Young et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Pharmacology & Pharmacy

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine

Selvanayagam Nirthanan

BIOCHEMICAL PHARMACOLOGY (2020)

Article Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

Stephanie Pfaender et al.

NATURE MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression

Mong-Lien Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Polysaccharide isolated from persimmon leaves (Diospyros kaki Thunb.) suppresses TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells

Won-Chul Lim et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Medicine, Research & Experimental

Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis

Devivasha Bordoloi et al.

LIFE SCIENCES (2020)

Review Biochemistry & Molecular Biology

Exosomes: key players in cancer and potential therapeutic strategy

Jie Dai et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Pharmacology & Pharmacy

Acetylcholine signaling system in progression of lung cancers

Jamie R. Friedman et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Review Oncology

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Haval Balata et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

Article Pharmacology & Pharmacy

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

Elena V. Kryukova et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Virology

Emerging Role of LY6E in Virus-Host Interactions

Jingyou Yu et al.

VIRUSES-BASEL (2019)

Article Health Policy & Services

Smoking and Smoking Cessation Among Persons with Tobacco- and Non-tobacco-Associated Cancers

M. Shayne Gallaway et al.

JOURNAL OF COMMUNITY HEALTH (2019)

Review Oncology

Perception of Lung Cancer Risk: Impact of Smoking Status and Nicotine Dependence

Laurent Greillier et al.

CURRENT ONCOLOGY REPORTS (2018)

Article Biochemistry & Molecular Biology

Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer

Courtney M. Schaal et al.

MOLECULAR CANCER (2018)

Article Pharmacology & Pharmacy

α9-and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line

Vanessa Mucchietto et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Reciprocal activation of α5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation

Yao Zhang et al.

JOURNAL OF GENETICS AND GENOMICS (2017)

Article Plant Sciences

AtCNGC2 is involved in jasmonic acid-induced calcium mobilization

Min Lu et al.

JOURNAL OF EXPERIMENTAL BOTANY (2016)

Review Oncology

The Oncogenic Functions of Nicotinic Acetylcholine Receptors

Yue Zhao

JOURNAL OF ONCOLOGY (2016)

Review Genetics & Heredity

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Chelsea L. Loughner et al.

HUMAN GENOMICS (2016)

Article Pathology

α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells

Haiji Sun et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2015)

Editorial Material Immunology

Recent progress in revealing the biological and medical significance of the non-neuronal cholinergic system

Sergei A. Grando et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)