4.7 Article

5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment

Journal

CARBOHYDRATE POLYMERS
Volume 273, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118523

Keywords

Cellulose; Fe3O4-nanoparticles; Composites; 5-Fluorouracil; Drug carrier system; Colorectal cancer; Microfluidic; Co-culture

Funding

  1. Takasago Thermal Engineering Co. Ltd. grant from the research management center (RMC) of Universiti Teknologi Malaysia (UTM) [R.K.130000.7343.4B422]
  2. Fundamental Research Grant Scheme from the research management center (RMC) of Universiti Teknologi Malaysia (UTM) [R.K130000.7843.5F403]
  3. Malaysia Japan International Institute of Technology (MJIIT)
  4. Sunway University [GRTIN-RSF-SHMS-DMS-03-2020]
  5. University of Hradec Kralove Excellence project [PrF UHK 2011/2021-2022]

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The study developed a multifunctional magnetic cellulose nanocomposite MC/5-FU, demonstrating potential as a low-cost drug carrier for colorectal cancer treatments.
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 degrees C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.

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