Tunable arrangement of hydrogel and cyclodextrin-based metal organic frameworks suitable for drug encapsulation and release

The present study focused on the integration of beta-cyclodextrin based metal-organic frameworks (fl-CDMOF) with polymer to obtain hybrid materials with advantageous properties compared to traditional single-component polymers or metal-organic frameworks (MOF) matrixes. We fabricated two complexes with different morphology and structure. During the in situ growth of fl-CDMOF around the hydrogel, potassium ions on polysaccharides gradually dissociated to participate in the growth of crystals, while other potassium ions on the carboxylic acid groups provided bridges between crystals and hydrogel, forming a necklace-shaped complex (SHPs@fl-CDMOF). Hydrogen bonding and coordination interactions between fl-CDMOF and hydrogel are present in a dendritic sandwich-shaped complex (fl-CDMOF@SHPs). Furthermore, using the hydrophobic molecule curcumin as a model drug, we have demonstrated that SHPs@fl-CDMOF and fl-CDMOF@SHPs hybrid materials stabilize the included drug and have potential for controlled drug release. Collectively, the integration of MOF with polymer holds a great promise for drug delivery applications.

Automated summary

The integration of beta-cyclodextrin based metal-organic frameworks with polymer has been shown to result in hybrid materials with advantageous properties and potential for drug delivery applications.